USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P62333 USC-OGP 2-DE database:  P62333 P62333 General information about the entry View entry in simple text format Entry name PRS10_HUMAN Primary accession number P62333 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=26S protease regulatory subunit 10B; AltName: Full=26S proteasome AAA-ATPase subunit RPT4; AltName: Full=Proteasome 26S subunit ATPase 6; AltName: Full=Proteasome subunit p42;. Gene name Name=PSMC6 Synonyms=SUG2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1191: pI=7.06; Mw=41736 Cross-references UniProtKB/Swiss-Prot P62333; PRS10_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRS10_HUMAN Primary accession number P62333 Secondary accession number(s) B2R975 P49719 Q6IBU3 Q92524 Sequence was last modified on  July 5, 2004 (version 1) Annotations were last modified on  March 15, 2017 (version 143) Name and origin of the protein Description RecName: Full=26S protease regulatory subunit 10B; AltName: Full=26S proteasome AAA-ATPase subunit RPT4; AltName: Full=Proteasome 26S subunit ATPase 6; AltName: Full=Proteasome subunit p42; Gene name Name=PSMC6 Synonyms=SUG2 Encoded on Name=PSMC6; Synonyms=SUG2 Keywords 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D78275; BAA11338.1; -; mRNA EMBL AF006305; AAB61616.1; -; mRNA EMBL BT006843; AAP35489.1; -; mRNA EMBL CR456709; CAG32990.1; -; mRNA EMBL AK313670; BAG36422.1; -; mRNA EMBL CH471078; EAW65645.1; -; Genomic_DNA EMBL BC005390; AAH05390.1; -; mRNA PIR S71316; S71316; . RefSeq NP_002797.3; NM_002806.3; . UniGene Hs.156171; -; . PDB 5GJQ; EM; 4.50 A; L=1-389 PDB 5GJR; EM; 3.50 A; L/z=1-389 PDB 5L4G; EM; 4.02 A; L=1-389 PDB 5T0C; EM; 3.80 A; AE/BE=1-389 PDB 5T0G; EM; 4.40 A; E=1-389 PDB 5T0H; EM; 6.80 A; E=1-389 PDB 5T0I; EM; 8.00 A; E=1-389 PDB 5T0J; EM; 8.00 A; E=1-389 PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4G; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal P62333; -; . SMR P62333; -; . BioGrid 111679; 118; . DIP DIP-38150N; -; . IntAct P62333; 58; . MINT MINT-5001174; -; . STRING 9606.ENSP00000401802; -; . iPTMnet P62333; -; . PhosphoSitePlus P62333; -; . SwissPalm P62333; -; . BioMuta PSMC6; -; . DMDM 51702772; -; . REPRODUCTION-2DPAGE IPI00021926; -; . EPD P62333; -; . MaxQB P62333; -; . PaxDb P62333; -; . PeptideAtlas P62333; -; . PRIDE P62333; -; . DNASU 5706; -; . Ensembl ENST00000606149; ENSP00000475721; ENSG00000100519; . GeneID 5706; -; . KEGG hsa:5706; -; . UCSC uc059bor.1; human; . CTD 5706; -; . DisGeNET 5706; -; . GeneCards PSMC6; -; . H-InvDB HIX0011661; -; . HGNC HGNC:9553; PSMC6; . HPA HPA042823; -; . MIM 602708; gene; . neXtProt NX_P62333; -; . OpenTargets ENSG00000100519; -; . PharmGKB PA33898; -; . eggNOG KOG0651; Eukaryota; . eggNOG COG1222; LUCA; . GeneTree ENSGT00550000074826; -; . HOGENOM HOG000225143; -; . HOVERGEN HBG000109; -; . InParanoid P62333; -; . KO K03064; -; . PhylomeDB P62333; -; . TreeFam TF106229; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . GeneWiki PSMC6; -; . GenomeRNAi 5706; -; . PRO PR:P62333; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000100519; -; . CleanEx HS_PSMC6; -; . ExpressionAtlas P62333; baseline and differential; . Genevisible P62333; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0031597; C:cytosolic proteasome complex; IBA:GO_Central; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0031595; C:nuclear proteasome complex; IBA:GO_Central; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0022624; C:proteasome accessory complex; ISS:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0008540; C:proteasome regulatory particle; base subcomplex; IBA:GO_Central GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0016887; F:ATPase activity; TAS:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0036402; F:proteasome-activating ATPase activity; IBA:GO_Central; . GO GO:0030674; F:protein binding; bridging; NAS:UniProtKB GO GO:0017025; F:TBP-class protein binding; IBA:GO_Central; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IBA:GO_Central; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IBA:GO_Central; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0006511; P:ubiquitin-dependent protein catabolic process; IC:UniProtKB; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 3.40.50.300; -; 1; . InterPro IPR005937; 26S_Psome_P45; . InterPro IPR003593; AAA+_ATPase; . InterPro IPR003959; ATPase_AAA_core; . InterPro IPR003960; ATPase_AAA_CS; . InterPro IPR027417; P-loop_NTPase; . Pfam PF00004; AAA; 1; . SMART SM00382; AAA; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR01242; 26Sp45; 1; . PROSITE PS00674; AAA; 1; .

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